99% of the population in Muara Enim Regency is Muslim.

The Muslim population in Muara Enim Regency, as of December 31, 2023, was recorded at 632,400. Compared to the previous year, the number of Muslims in the regency/city increased by 17,826.

According to data from the Directorate General of Population and Civil Registration (Ditjen Dukcapil) of the Ministry of Home Affairs, the proportion of Muslims in this regency/city reached 99 percent of the total population in 2023, which was 640,220.

Considering the distribution across the districts in South Sumatra, the proportion of Muslims in Muara Enim Regency ranks sixth.

Below is the population of South Sumatra by religion in 2023:
* Islam 632,396 (98.78%)
* Protestant 4,194 (0.66%)
* Hindu 1,482 (0.23%)
* Catholic 1,401 (0.22%)
* Buddhist 751 (0.12%)
* Confucian 0 (0.0%)
* Indigenous Beliefs 0 (0.0%)

Other regencies/cities in South Sumatra with the largest Muslim populations are: Palembang City 1,657,373, Banyuasin Regency 833,934, Ogan Komering Ilir Regency 760,994, Musi Banyuasin Regency 693,281, Ogan Komering Ulu Timur Regency 649,536, Ogan Ilir Regency 438,257, Lahat Regency 438,137, Ogan Komering Ulu Selatan Regency 418,232, Musi Rawas Regency 412,458, and Ogan Komering Ulu Regency 373,976.